Pathological Conditions (Comorbidities)

Nowadays, we know for sure that psoriasis is associated with several other diseases (comorbidities) and that a psoriatic patient may also develop other disorders. Some of these have been known for some time – e.g. Psoriatic Arthritis that according to the currently available statistics, involves 20 to 30% of psoriatic patients.

Patients suffering from chronic inflammatory bowel diseases such as Crohn’s disease, have a higher prevalence of psoriasis compared to the general population. This sort of bowel diseases are often associated with other inflammatory disorders both at skin and eye level – e.g. uveitis. This suggests there might be some sort of link between bowels, skin and eyes.

Some types of metabolic diseases have been recently associated with Psoriasis, namely diabetes, hyperuricemia, hypercholesterolemia, an increase in weight and body mass up to obesity.

Recent observational studies have allowed us to establish that the risk to develop hypertension is 2 times higher in psoriatic patients and that this overall risk may lead to a greater risk of cardiovascular diseases. This risk is greater in case of more severe psoriasis.

What is behind these comorbidities? Probably a genetic risk, definitely wrong lifestyles, smoking or excessive weight/obesity, but also the chronic inflammation of the skin that releases other substances – currently being established – that can cause a cardiovascular damage.

Thus, the need to ‘cure’ the disease in the most effective and long-lasting manner in order to stop the vicious circle behind some comorbidities.


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